Dynamic Catalytic Highly Enantioselective 1,3?Dipolar Cycloadditions

In dynamic covalent chemistry, reactions follow a thermodynamically controlled pathway through equilibria. Reversible covalent-bond formation and breaking in process enables the interconversion of products formed under kinetic control to more stable isomers. Notably, enantioselective catalysis transformations has not been reported applied complex molecule synthesis. We describe discovery metal-complex-catalyzed 1,3-dipolar cycloaddition reactions. have developed stereodivergent tandem synthesis structurally stereochemically molecules that generates eight stereocenters with high diastereo- enantioselectivity asymmetric reversible bond two consecutive Ag-catalyzed cycloadditions azomethine ylides electron-poor olefins. Time-dependent gives enantiodivergent diastereodivergent access double cycloadducts selectivity from common set reagents.